GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs757978 | 1 | rs73116396 | chr2:242368693 | SEPT2 | chr2:242254723-242293439:+ | 0.44 | 6.02 | 3.32E-8 | Chronic lymphocytic leukemia |
| THYM | cis | rs2243480 | 1 | rs73142121 | chr7:65311206 | CCT6P1 | chr7:65216092-65228661:+ | 0.65 | 4.84 | 4.96E-6 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs73142122 | chr7:65311298 | CCT6P1 | chr7:65216092-65228661:+ | 0.68 | 5.01 | 2.55E-6 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs73142162 | chr7:65374296 | CCT6P1 | chr7:65216092-65228661:+ | 0.68 | 5.01 | 2.55E-6 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs73142166 | chr7:65375832 | CCT6P1 | chr7:65216092-65228661:+ | 0.67 | 4.78 | 6.27E-6 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs73150014 | chr7:65450919 | CCT6P1 | chr7:65216092-65228661:+ | 0.64 | 5.31 | 7.19E-7 | Diabetic kidney disease |
| THYM | cis | rs7989332 | 1 | rs7320606 | chr13:21052521 | GJB2 | chr13:20761606-20767114:- | -0.36 | -4.68 | 9.62E-6 | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) |
| THYM | cis | rs7989332 | 1 | rs7329823 | chr13:21050127 | GJB2 | chr13:20761606-20767114:- | -0.36 | -4.82 | 5.51E-6 | Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) |
| THYM | cis | rs911119 | 1 | rs73318135 | chr20:23618571 | CST9 | chr20:23583049-23586610:- | -0.47 | -4.17 | 6.74E-5 | Chronic kidney disease |
| THYM | cis | rs7223966 | 1 | rs73337598 | chr17:61732576 | TCAM1P | chr17:61934376-61941738:+ | -0.54 | -4.45 | 2.32E-5 | Body mass index |
| THYM | cis | rs911119 | 1 | rs734801 | chr20:23612791 | CST9 | chr20:23583049-23586610:- | -0.51 | -4.71 | 8.44E-6 | Chronic kidney disease |
| THYM | cis | rs10935120 | 1 | rs7356093 | chr3:134238753 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 8.05 | 2.33E-12 | Height |
| THYM | cis | rs10935120 | 1 | rs7356093 | chr3:134238753 | CEP63 | chr3:134204575-134293852:+ | 0.4 | 5.81 | 8.19E-8 | Height |
| THYM | cis | rs2806864 | 1 | rs7366434 | chr1:117455553 | SLC22A15 | chr1:116519119-116612672:+ | -0.64 | -4.26 | 4.74E-5 | Erectile dysfunction and prostate cancer treatment |
| THYM | cis | rs10935120 | 1 | rs7371896 | chr3:134249769 | ANAPC13 | chr3:134196547-134204865:- | 0.58 | 7.96 | 3.67E-12 | Height |